English: Built in 1870, this Richardsonian Romanesque-style former psychiatric hospital was designed by Henry Hobson Richardson to serve the population of the rapidly growing urban areas in Western New York with more advanced mental health treatment. Sitting among a large park-like campus designed by Frederick Law Olmsted and Calvert Vaux, the rusticated Medina red sandstone and brick structures of the hospital are laid out primarily according to the Kirkbride plan. The the largest commission by footprint and square footage designed by Richardson during his storied and significant career, being one of the earliest examples of his signature Richardsonian Romanesque style, which mixes rusticated stone with Romanesque architecture to create romantic picturesque compositions reminiscent of Medieval castles and churches in Europe.

The campus was expanded over time with the construction of additional wings in red brick on either side of the original Medina sandstone buildings, which consists of the central five wings, the three brick wings at the eastern end of the complex having been removed in the 1970s to make way for a modern psychiatric facility, despite the complex’s historic and architectural significance having been recognized during the 1960s. Additional buildings not in the kirkbride formation were scattered around the grounds, including a greenhouse behind the main building, several smaller service and utility buildings, and buildings that were constructed to provide additional wards to house patients during the early 20th Century, as well as buildings meant to house staff.

When the hospital was in operation, patients were segregated by sex, with male patients being housed in the eastern pavilions, and female patients being housed in the western pavilions. The building was utilized as a psychiatric hospital known as the Buffalo State Asylum until the 1970s, when changing methods of treating psychiatric illness were developed, leading to the building becoming obsolete and newer facilities being built on the grounds. The central wing of the complex, however, remained in use as administrative offices for the still-operating psychiatric treatment facilities on the property until 1994.

The building went through a period of significant and prolonged deterioration and uncertainty between the 1970s and 2008, with the unsecured facility becoming vandalized, decayed, and unsafe. However, in 2008, in the wake of a successful lawsuit filed by the Preservation Coalition of Erie County, the State of New York was forced to commit $100 million in order to rehabilitate the structure. Between the spring of 2008 and the fall of 2012, the complex was stabilized, and in 2013, the South Lawn was converted from parking lots back into the original, verdant green space it was meant to be. In 2017, the first phase of the building's adaptive reuse and rehabilitation was completed, which transformed the central three pavilions into the Hotel Henry and Conference Center, with the Buffalo Architecture Center also opening in the renovated structure. The plans for the complex were to convert the remaining intact but vacant pavilions into additional space for the Hotel Henry Urban Resort Conference Center, which would have been spectacular once it transformed and revitalized the amazing historic structure. However, due to restrictions and economic effects relating to the recent pandemic, Hotel Henry became insolvent and closed in 2021.

The complex consisted of a central wing with two tall towers that housed administrative facilities, flanked by five pavilions on each side, which progressively stair-step north from the central pavilion, a key feature of the Kirkbride plan, with a total of 11 structures in the complex, with three brick pavilions having been removed from the east side of the complex. The central wing features two towers with steeply-pitched copper-clad roofs, turrets at the corners, shed dormers, and corbeling, hipped dormers of varying sizes, with recessed panels and windows of varying sizes helping tie it back to its medieval aesthetic inspiration. The wing also features wall dormers, windows with arched transoms and stone trim, gabled roofs, and two-story arced connecting corridors that link it to the pavilions next to it on either side, features that are shared with the other medina sandstone buildings in the Richardson-designed portion of the complex. The front of the central wing features a porch with arched openings supported by columns with ornate capitals, tile mosaics on the faces of the vaults and blind arches on the porch, and a central doorway with an arched transom. The rear facade has been slightly modified with the installation of a curtain wall where an addition had been connected to the building in the mid-20th Century, which was added to serve as a primary and fully accessible entrance to the hotel that formerly operated in the building, with a large metal canopy having been added to this side of the building in 2021-22. To either side of the main wing are a total of four medina sandstone wings that formerly housed patient wards, which are largely identical and feature hipped and gabled roofs, wall dormers, windows with stone trim and arched transoms, arced two-story connecting corridor structures, and chain link-enclosed steel and concrete porches on the unrestored outer wings, which were once present on all of the wards, but were removed on the wards that were restored.

To the north and west of the sandstone structure are a series of red brick wings and buildings in various states of deterioration, with the two western wings being similar in appearance to the medina sandstone wings, but one floor shorter, blocky four-story red brick wings with low-slope roofs to the rear of the outermost sandstone wings, and two one-story service buildings behind the middle wings that flank the central wing, which feature hipped roofs, and differ a lot in materiality and details. At the very end of the western wings is a wing that is turned 90 degrees from the wing it is attached to and is roughly H-shaped, being only one story in height, featuring a gabled roof, a wooden porch with doric columns at the northwest corner, and a one-story bay window in the middle of the north facade. These wings are in much worse condition than the sandstone portions of the complex.

The complex was listed on the National Register of Historic Places in 1973, and was named a National Historic Landmark in 1986. The complex’s future is presently uncertain, with a large section of copper missing from the north side of the roof of the east tower on the central wing, many of the wings still languishing in abandonment and severe disrepair, and no longer having an anchoring business to preserve and reuse the buildings.