MAPK4

MAPK4
Identifiers
Aliases	MAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDs	OMIM: 176949 MGI: 2444559 HomoloGene: 2058 GeneCards: MAPK4
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,731,826 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	74,065,359 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; amygdala; ; prefrontal cortex; ; Brodmann area 9; ; left ventricle; ; hypothalamus; ; ganglionic eminence; ; popliteal artery;
	Top expressed in
	olfactory tubercle; ; habenula; ; visual cortex; ; superior frontal gyrus; ; primary motor cortex; ; prefrontal cortex; ; globus pallidus; ; cingulate gyrus; ; cerebellar cortex; ; median eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; kinase activity; protein heterodimerization activity; nucleotide binding; protein kinase binding; protein homodimerization activity; protein kinase activity; transferase activity; protein binding; MAP kinase activity;
Cellular component	cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	protein phosphorylation; cell cycle; phosphorylation; MAPK cascade; regulation of gene expression; cellular response to organic substance; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5596
	225724
	ENSG00000141639; ENSG00000282110
	ENSMUSG00000024558
	P31152
	Q6P5G0
	NM_001292039; NM_001292040; NM_002747
	NM_172632; NM_001360936
	NP_001278968; NP_001278969; NP_002738
	NP_766220; NP_001347865
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.^[5]^[6]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.^[6]

The Arabidopsis MAPK4 is important in signalling ^[7]

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.^[8]

References[edit]

^ ^a ^b ^c ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024558 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li L, Wysk M, Gonzalez FA, Davis RJ (February 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
^ ^a ^b "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
^ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, et al. (December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111–20. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186. S2CID 1864451.
^ Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, et al. (March 2019). "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling". The Journal of Clinical Investigation. 129 (3): 1015–1029. doi:10.1172/JCI97712. PMC 6391107. PMID 30688659.

External links[edit]

MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024558 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8290275-5] Li L, Wysk M, Gonzalez FA, Davis RJ (February 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.

[entrez-6] "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".

[7] Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, et al. (December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111–20. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186. S2CID 1864451.

[8] Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, et al. (March 2019). "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling". The Journal of Clinical Investigation. 129 (3): 1015–1029. doi:10.1172/JCI97712. PMC 6391107. PMID 30688659.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References[edit]

Further reading[edit]

External links[edit]